Trial document




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  DRKS00004596

Trial Description

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Title

Reaction Time - Alignment of Late Positive ERP Components to Linguistic Deviations ("P600")

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Trial Acronym

P600RT

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URL of the Trial

[---]*

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Brief Summary in Lay Language

We want to measure if certain brain effects are related to complex analysis of speech, or are due to more general processes. Subjects will listen to sentences containing errors while we record their EEG. We then want to investigate if the brain effects after such errors are more closely related to the timing of the errors, or the press of a button by the subject indicating they have found an error.

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Brief Summary in Scientific Language

The study is supposed to investigate if certain brain effects following linguistic deviations reflect high-level linguistic analysis, or more general processes.
The P600 effect of the ERP has long been understood as a marker of syntactic processing by some (Hagoort et al., 1993, Friederici et al., 1995), and as a late P300 (a low-level, general marker of state change) by others (Coulson et al., 1999, Kretzschmar et al., 2010). The P300 has been associated with the Noradrenaline release from the Locus Coeruleus (Nieuwenhius et al., 2005) following a stimulus requiring reorienting behavior, and is temporally more tightly associated with the following reorientation behavior than with the stimulus.

Subjects will listen to sentences containing deviancies known to elicit P600 effects while their EEG is recorded and are supposed to respond with button presses to detected deviancies.
Subjects will be assembled from a pool of university students at the Uni Mainz.
Our main hypotheses concern the reaction time alignment of the positive component following detected deviancies. We expect that it will be tightly aligned to button press if it reflects general state change FOLLOWING linguistic analysis) whereas components are expected to be aligned to stimulus onset if they reflect the actual analysis).
The P600 is expected to show up as a positive deflection peaking approximately 600 ms after deviant word onset.

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Organizational Data

  •   DRKS00004596
  •   2013/01/08
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  •   yes
  •   No approval required according to EC
  •   [---]*
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Secondary IDs

  •   U1111-1137-7584 
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Health Condition or Problem studied

  •   Healthy Participants
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Interventions/Observational Groups

  •   Measurement of EEG of Students at the University of Mainz during speech stimulus presentation
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Characteristics

  •   Non-interventional
  •   Other
  •   Single arm study
  •   Open (masking not used)
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  •   Uncontrolled/Single arm
  •   Basic research/physiological study
  •   Single (group)
  •   N/A
  •   N/A
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Primary Outcome

Single-trial-alignment of P600 effects to onset of critical (syntactically deviating) word vs. following reaction time will be measured thusly:
All participant's single-trial EEG epochs centered around the onset of deviating words will be plotted using ERPimages (Jung et al., 2001) sorted by reaction time (RT). The average of these trials is expected to show a positive deflection peaking approximately 600ms after onset. In RT-sorted ERPimages, stimulus-aligned effects show up as straight vertical lines (parallel to stimulus onset), RT-aligned effects show up as curved, RT-aligned lines.
We will investigate centro-parietal electrodes (electrode Pz and its neighbors).

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Secondary Outcome

We will also investigate the onset/RT-alignment of other language-related ERP components (N400, LAN, N2), as well as possible attentional blink phenomena (a second target appearing during the P300 of the previous target) and compare the effects between semantic and syntactic deviations in their scalp topology.

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Countries of Recruitment

  •   Germany
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Locations of Recruitment

  • other 
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Recruitment

  •   2013/01/25
  •   Actual
  •   16
  •   Monocenter trial
  •   National
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Inclusion Criteria

  •   Both, male and female
  •   18   Years
  •   50   Years
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Additional Inclusion Criteria

Native Speaker of German

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Exclusion Criteria

Neurological abnormalities

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Addresses

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    • Universität Marburg
    • Mr.  Jona  Sassenhagen 
    • Deutschhausstraße 3
    • 35033  Marburg
    • Germany
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    • Universität Marburg
    • Mr.  Jona  Sassenhagen 
    • Deutschhausstraße 3
    • 35033  Marburg
    • Germany
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    end of 1:1-Block address contact scientific-contact
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    • Universität Marburg
    • Mr.  Jona  Sassenhagen 
    • Deutschhausstraße 3
    • 35033  Marburg
    • Germany
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Sources of Monetary or Material Support

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    • Universität Marburg
    • Mr.  Jona  Sassenhagen 
    • Deutschhausstraße 3
    • 35033  Marburg
    • Germany
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Status

  •   Recruiting complete, follow-up complete
  •   2013/02/15
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Trial Publications, Results and other Documents

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* This entry means the parameter is not applicable or has not been set.